Preparation of acetanilide college of science chemistry department 1 preparation and purification of acetanilide purpose. Preparation acetanilide aniline from aniline in the laboratory. I know that i of nitrogen must decrease the yield of ortho product, but still it should be made in accountable amounts. Preparation of acetanilide from aniline pharmadunia. Acetanilide is prepared from aniline when it reacts with acetic anhydrideglacial acetic acid in the presence of zinc dust. The freshly redistilled aniline, is almost a colourless oily liquid which being practically insoluble in water. A mixture of aniline, glacial acetic acid, acetic anhydride and zinc dust is refluxed under anhydrous condition and then poured the mixture into ice cold water to get acetic anhydride precipitate.
In this experiment acetanilide is synthesized from aniline, acetic anhydride and acetic acid. Therefore, before carrying out the acetylation aniline has got to be made soluble in the aqueous medium. Its preparation method is used to introduce students with synthesis of organic compounds in chemistry labs. Chem261 nitration of acetanilide followup 162 duration. Synthesis of acetanilide from aniline organic chemistry. Concentrated hydrochloric acid can cause severe burns. Aniline is refluxed with glacial acetic acid in the presence of fused sodium acetate when acetanilide is obtained. Acetanilide is prepared from aniline by acetylating it with acetic anhydride in the presence of glacial acetic acid. To prepare and submit acetanilide from aniline labmonk. But before aniline comes out of the h2o solution, itqu ck lyod es. Acetanilide is slightly soluble in water, and stable under most conditions.
Aniline is toxic and can be absorbed through the skin. The crude precipitate of acetic anhydride is recrystallized to get pure crystals of acetanilide. Preparation of acetanilide chemistry practicals class 12 byjus. It can be accomplished by adding requisite amount of concentrated hcl whereby the highly reactive amino function easily takes up a proton from the dissociation of. Acetanilide definition of acetanilide by merriamwebster. Acetanilide is synthesized from aniline by acetylating it with acetic anhydride in presence of glacial acetic acid. Synthesis of acetamides from aniline and substituted anilines. This is the method used in the preparation of acetanilide from aniline. Acetanilide definition is a white crystalline compound c8h9no that is derived from aniline and acetic acid and is used especially to relieve pain or fever. Why meta nitro aniline is formed during nitration of aniline. Both aniline and acetic anhydride are somewhat viscous liquids. Preparation of acetanilide chemistry practicals class 12.